SYNTHESIS OF NOVEL XANTHINE DERIVATIVES AND EVALUATION OF THEIR HYPOPHAGIC EFFECT

The objective of this work was to synthesize xanthine derivatives and evaluate the anti-obesity action.The compounds were yellow to brown in color and obtained in 68-71 % yields and were slightly soluble in water, insoluble in methanol and DMSO while they were soluble in chloroform.The confirmation of the structures of the compounds was done by 1 H-NMR, mass and IR spectral study.Compounds 4a-e were found to be hypophagic and restrict the intake of food by the mice and the hyperphagic effect of () -8-OH-DPAT was antagonized by them.