Screening of metabolic markers in pediatric epilepsy disorders
This study identified and validated peripheral blood metabolites in children with epilepsy. OA was found to exert a protective effect via GPR40 activation, enhancing neuroprotection. These findings suggest that OA may play a critical role in neuroprotection and could serve as a potential therapeutic target for pediatric epilepsy.
Authors
- Jian Xu (ORCID: https://orcid.org/0000-0001-5448-3034)
- Yansheng Ding
- Yu Chen (ORCID: https://orcid.org/0000-0003-4458-4039)
- Wang Yu-hui (ORCID: https://orcid.org/0009-0002-3726-2058)
- Biwen Peng
- Shuo Kong
Institutions
- Weifang Medical University (CN)
- Wuhan University (CN)
- Weifang People's Hospital (CN)
- Weifang Maternity and Child Care Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s12967-025-06917-1
- Citations
- 2
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.64