FGL1-mediated lymph node metastasis in stage T1 non-small cell lung cancer: therapeutic targeting
We elucidated the role of FGL1 in NSCLC, proposing that FGL1 acts like a "shield machine cutter" in mediating T1 NSCLC N2 lymph node tube formation, creating metastasis channels. This provides the basis for novel FGL1-targeting treatment strategies.
Authors
- Nan Ma (ORCID: https://orcid.org/0000-0003-4494-3337)
- Du Weiguang
- Feng Zhi-bo
- Runbing Zhang
- Xiaolong Yan (ORCID: https://orcid.org/0000-0003-2419-9707)
- Xiyang Tang
- M. Li
- Yang Shen (ORCID: https://orcid.org/0000-0002-4682-4852)
- Yulong Zhou
- Chen Shu (ORCID: https://orcid.org/0000-0003-0440-5403)
- Jinbo Zhao (ORCID: https://orcid.org/0000-0002-7806-6072)
- Jun-Chao Cai
Institutions
- Sun Yat-sen University (CN)
- Tang Du Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s40164-025-00709-5
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China