Cochlear-bioelectrode: Auditory response to cochlear implant can be improved by stem cell delivery into inner ear in a pig model
Our results showed that in vivo concurrent cochlear implant stimulation and hipsc delivery increased stem cells in the sgn region and lowered ci stimulation thresholds, paving the way to broad and promising clinical applications.
Authors
- Liangwei Xu
- Lili Ren (ORCID: https://orcid.org/0000-0002-6645-8183)
- Weiwei Guo (ORCID: https://orcid.org/0000-0002-2001-7956)
- Shiming Yang (ORCID: https://orcid.org/0000-0002-7808-2566)
- Liang Zhang (ORCID: https://orcid.org/0000-0003-2369-3578)
- Jianan Li (ORCID: https://orcid.org/0000-0002-9776-2129)
- Wei Sun (ORCID: https://orcid.org/0000-0003-4610-6161)
- Fei Ji (ORCID: https://orcid.org/0000-0003-3002-9798)
- Shuolong Yuan
- Wei Chen (ORCID: https://orcid.org/0000-0002-0113-2596)
Institutions
- Ball State University (US)
- Chinese PLA General Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Chongqing Academy of Animal Science (CN)
- University at Buffalo, State University of New York (US)
- Beijing Information Science & Technology University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s13287-025-04583-0
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Natural Science Foundation of China
- National Key Research and Development Program of China