Fatal acute miliary tuberculosis complicated by obstructive jaundice, acute pancreatitis, and hemophagocytic lymphohistiocytosis in a 57-year-old immunocompetent female: a case report

Miliary tuberculosis may present with nonspecific features and symptoms, and a thorough correlation between clinical examination, radiological findings, and laboratory tests is required to establish the diagnosis. The delayed diagnosis and treatment of miliary tuberculosis majorly affect patient outcomes. The progression of the disease is unpredictable, and several complications, although rare, may occur all at once, emphasizing the importance of multidisciplinary collaboration between specialists. Hemophagocytic lymphohistiocytosis symptoms may overlap with miliary tuberculosis symptoms, and antituberculosis therapy medications are irreplaceable in the treatment of tuberculosis-related hemophagocytic lymphohistiocytosis. Immunocompetence is not a basis for excluding miliary tuberculosis.

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Publication Details

Journal
Journal of Medical Case Reports
Published
2025-09-29
DOI
https://doi.org/10.1186/s13256-025-05558-8
Primary Topic
Diagnosis and treatment of tuberculosis
Type
article
Field-Weighted Citation Impact
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article

Fatal acute miliary tuberculosis complicated by obstructive jaundice, acute pancreatitis, and hemophagocytic lymphohistiocytosis in a 57-year-old immunocompetent female: a case report

Mario Wassel, Saja Karaja, Suleiman Khaddour, Ahed Assaf et al.
Journal of Medical Case Reports
Diagnosis and treatment of tuberculosis
article

Fatal acute miliary tuberculosis complicated by obstructive jaundice, acute pancreatitis, and hemophagocytic lymphohistiocytosis in a 57-year-old immunocompetent female: a case report

Mario Wassel, Saja Karaja, Suleiman Khaddour, Ahed Assaf, William Borghol, Haya Almohammad, Kinan Alkeshk, Akram Shammat
article en

Abstract

Miliary tuberculosis may present with nonspecific features and symptoms, and a thorough correlation between clinical examination, radiological findings, and laboratory tests is required to establish the diagnosis. The delayed diagnosis and treatment of miliary tuberculosis majorly affect patient outcomes. The progression of the disease is unpredictable, and several complications, although rare, may occur all at once, emphasizing the importance of multidisciplinary collaboration between specialists. Hemophagocytic lymphohistiocytosis symptoms may overlap with miliary tuberculosis symptoms, and antituberculosis therapy medications are irreplaceable in the treatment of tuberculosis-related hemophagocytic lymphohistiocytosis. Immunocompetence is not a basis for excluding miliary tuberculosis.

Journal of Medical Case ReportsVol. 19(1)
Latakia University (SY), Binghamton University (US), Häme University of Applied Sciences (FI)
Openalex Percentile: Top 57%
Diagnosis and treatment of tuberculosis
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