Simultaneous measurement of apalutamide and N-desmethylapalutamide in human plasma using high-performance liquid chromatography with ultraviolet detection
This work therefore presents a robust and simple HPLC-UV method for the simultaneous quantification of apalutamide and N-desmethylapalutamide in clinical therapeutic drug monitoring.
Authors
- Kazutaka Saito (ORCID: https://orcid.org/0000-0002-7261-0188)
- Toshinori Hirai (ORCID: https://orcid.org/0000-0002-3898-2068)
- Masashi Nagata (ORCID: https://orcid.org/0000-0003-3169-7210)
- Keita Izumi (ORCID: https://orcid.org/0000-0002-9785-6432)
- Yasuyoshi Ishiwata
- Kouichiro Tsuge
Institutions
- University of Tokyo Hospital (JP)
- Dokkyo Medical University Saitama Medical Center (JP)
Publication Details
- Journal
- Journal of Pharmaceutical Health Care and Sciences
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s40780-025-00489-4
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00