Motion impact score for detecting spurious brain-behavior associations
In-scanner head motion introduces systematic bias to resting-state fMRI functional connectivity (FC) not completely removed by denoising algorithms. Researchers studying traits associated with motion (e.g. psychiatric disorders) need to know if their trait-FC relationships are impacted by residual motion to avoid reporting false positive results. We devised Split Half Analysis of Motion Associated Networks (SHAMAN) to assign a motion impact score to specific trait-FC relationships. SHAMAN distinguishes between motion causing overestimation or underestimation of trait-FC effects. We assessed 45 traits from n = 7270 participants in the Adolescent Brain Cognitive Development (ABCD) Study. After standard denoising with ABCD-BIDS and without motion censoring, 42% (19/45) of traits had significant (p < 0.05) motion overestimation scores and 38% (17/45) had significant underestimation scores. Censoring at framewise displacement (FD) < 0.2 mm reduced significant overestimation to 2% (1/45) of traits but did not decrease the number of traits with significant motion underestimation scores.
Authors
- Andrew N. Van (ORCID: https://orcid.org/0000-0002-8787-0943)
- Kristen M. Scheidter
- James C. Wilgenbusch (ORCID: https://orcid.org/0000-0001-9464-1578)
- Annie Zheng (ORCID: https://orcid.org/0000-0002-8047-9458)
- Olivia Doyle (ORCID: https://orcid.org/0000-0003-3957-2949)
- Dillan J. Newbold (ORCID: https://orcid.org/0000-0002-5826-3546)
- Benjamin P. Kay (ORCID: https://orcid.org/0000-0003-3628-8029)
- Nico U.F. Dosenbach (ORCID: https://orcid.org/0000-0002-6876-7078)
- Eric Feczko (ORCID: https://orcid.org/0000-0003-1337-5517)
- Deanna M. Barch (ORCID: https://orcid.org/0000-0003-1693-8506)
- Abraham Z. Snyder (ORCID: https://orcid.org/0000-0002-3379-9627)
- Lucille A. Moore (ORCID: https://orcid.org/0000-0002-7665-2713)
- David F. Montez (ORCID: https://orcid.org/0000-0003-1672-8218)
- Michaela Cordova (ORCID: https://orcid.org/0000-0002-6860-5159)
- Roselyne J. Chauvin (ORCID: https://orcid.org/0000-0001-5786-4705)
- Stephen M. Malone (ORCID: https://orcid.org/0000-0001-9201-7616)
- Damien A. Fair (ORCID: https://orcid.org/0000-0001-8602-393X)
- Scott Marek (ORCID: https://orcid.org/0000-0003-0032-9052)
- Brenden Tervo‐Clemmens (ORCID: https://orcid.org/0000-0002-9557-1126)
- Julia Monk
- Evan M. Gordon (ORCID: https://orcid.org/0000-0002-2276-5237)
- Jarod L. Roland (ORCID: https://orcid.org/0000-0002-1312-8826)
- Gregory M. Conan
- Óscar Miranda-Domínguez (ORCID: https://orcid.org/0000-0002-3622-0166)
- Benjamin J. Lynch (ORCID: https://orcid.org/0000-0001-7310-2022)
- Eric Earl (ORCID: https://orcid.org/0000-0001-5512-0083)
- Samuel R. Krimmel (ORCID: https://orcid.org/0000-0002-5198-1545)
- Joshua S. Siegel (ORCID: https://orcid.org/0000-0002-5752-3641)
- Ryland L. Miller (ORCID: https://orcid.org/0000-0002-9607-9491)
- Timothy O. Laumann
- Anders Perrone (ORCID: https://orcid.org/0000-0003-4376-8047)
- Nicole A. Seider (ORCID: https://orcid.org/0000-0003-1511-1515)
- Thomas Pengo (ORCID: https://orcid.org/0000-0002-9632-918X)
- Athanasia Metoki (ORCID: https://orcid.org/0000-0002-8945-269X)
- Vahdeta Suljic
- Anita Randolph (ORCID: https://orcid.org/0000-0002-5615-6042)
- Alice M. Graham (ORCID: https://orcid.org/0000-0002-1416-1193)
- Babatunde Adeyemo
Institutions
- University of Minnesota (US)
- University of San Diego (US)
- Oregon Health & Science University (US)
- Washington University in St. Louis (US)
- University of California San Diego (US)
- NYU Langone Health (US)
- Mallinckrodt (United States) (US)
- National Institute of Mental Health (US)
Publication Details
- Journal
- Nature Communications
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1038/s41467-025-63661-2
- Citations
- 4
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.72
Funders
- University of Pittsburgh
- National Institutes of Health
- McDonnell Center for Systems Neuroscience
- National Institute of Mental Health