Nitroxoline mitigates hepatic steatosis by enhancing cholesterol efflux and promoting bile acid synthesis through LRH-1 signaling
This study identifies Nit as a promising pharmacological candidate for MAFLD by modulating cholesterol metabolism and bile acid synthesis through LRH-1-mediated activation. These findings not only advance the understanding of metabolic liver disease pathogenesis but also support the development of innovative and accessible therapeutic strategies by leveraging existing compounds to improve health outcomes.
Authors
- Pei‐Ju Lien (ORCID: https://orcid.org/0000-0003-4644-1533)
- Rou‐Ling Cho (ORCID: https://orcid.org/0000-0002-8970-5562)
- Chih‐Feng Lien
- Yi‐Jhen Huang (ORCID: https://orcid.org/0000-0002-3690-3522)
- Yi-Ping Chuang
- Chin‐Sheng Lin (ORCID: https://orcid.org/0000-0002-5167-8327)
- Sy‐Jou Chen (ORCID: https://orcid.org/0000-0002-2105-7570)
- Wencheng Liu (ORCID: https://orcid.org/0000-0002-4830-3209)
Institutions
- National Defense Medical Center (TW)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s12944-025-02720-5
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00