Long non-coding RNA HMGCR suppresses vascular remodeling in streptozotocin-induced type 1 diabetic rats via interaction with THOC5
This study demonstrates that lncHMGCR suppresses VSMCs dysfunction under diabetic conditions by upregulating THOC5 expression, suggesting its potential as a therapeutic target for vascular remodeling in T1DM. However, these findings are based solely on animal models and in vitro experiments, and further validation in clinical samples is required to confirm translational relevance.
Authors
- Xianhong Xie (ORCID: https://orcid.org/0000-0002-4278-1023)
- Bingxuan Niu (ORCID: https://orcid.org/0000-0003-2499-329X)
- Nian‐Sheng Li
- Jun‐Lin Jiang (ORCID: https://orcid.org/0000-0002-9897-2523)
- Wei-Qiang Tong
- Shuangyi He
- Wen-Xuan Li
- S. Chen
Institutions
- Central South University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s40001-025-03205-y
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China