Activin receptor type IIA/IIB blockade increases muscle mass and strength, but compromises glycemic control in mice
Our findings demonstrate that, in accordance with human studies, ActRIIA/IIB blockade holds promise for increasing muscle mass, strength, and muscle insulin sensitivity. However, contrary to the improved glycemic control in humans, ActRIIA/IIB blockade in mice causes severe glucose intolerance and lowers voluntary physical activity. Our study underscores the complex metabolic and functional consequences of ActRIIA/IIB blockade, and highlight species differences on glycemic control, which warrant further investigation.
Authors
- Jonas R. Knudsen (ORCID: https://orcid.org/0000-0002-5471-491X)
- Andreas M. Fritzen (ORCID: https://orcid.org/0000-0001-8793-9739)
- Erik A. Richter (ORCID: https://orcid.org/0000-0002-6850-3056)
- Christian Brix Folsted Andersen (ORCID: https://orcid.org/0000-0001-6182-2436)
- Camilla Lund (ORCID: https://orcid.org/0000-0001-5162-7311)
- Emma Frank (ORCID: https://orcid.org/0000-0002-2294-952X)
- Frederik Duch Bromer (ORCID: https://orcid.org/0000-0002-6839-139X)
- Steffen H. Raun (ORCID: https://orcid.org/0000-0003-2050-505X)
- Joan Miquel Màrmol (ORCID: https://orcid.org/0009-0009-3962-1123)
- Pauline Blomquist (ORCID: https://orcid.org/0000-0001-6142-4577)
- Edmund Battey (ORCID: https://orcid.org/0000-0003-4465-7533)
- Marco Eijken (ORCID: https://orcid.org/0000-0002-9043-3971)
- Gabriele Mocciaro (ORCID: https://orcid.org/0000-0001-5392-0909)
- Lykke Sylow (ORCID: https://orcid.org/0000-0003-0905-5932)
- Carlos Henríquez‐Olguín (ORCID: https://orcid.org/0000-0002-9315-9365)
- Michala Carlsson (ORCID: https://orcid.org/0000-0001-7222-6912)
- Nicoline R. Andersen (ORCID: https://orcid.org/0000-0002-1512-2727)
- Mona Sadek Ali (ORCID: https://orcid.org/0000-0003-1152-3256)
- Andrea Irazoki (ORCID: https://orcid.org/0000-0002-3118-3247)
- Martina Kubec Højfeldt
- Andreas Lodber
Institutions
- University of Copenhagen (DK)
- Novo Nordisk (Denmark) (DK)
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.molmet.2025.102261
- Citations
- 1
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- Novo Nordisk
- Danmarks Frie Forskningsfond
- Faculty of Health and Medical Sciences, University of Western Australia
- Novo Nordisk Fonden
- Det Sundhedsvidenskabelige Fakultet, Københavns Universitet