Evaluation of the quality of the fixed-dose triple combination dispersible tablet for HIV-positive paediatric population after the continuous direct compression and batch manufacturing techniques
FDC dispersible tablets were successfully manufactured with CDC and batch methods. Moreover, the product integrity results were similar for both the production technologies. However, the formulation and pre-blends require further optimization particularly for poorly flowable active pharmaceutical ingredients.
Authors
- Baatile Komane
- David R. Katerere (ORCID: https://orcid.org/0000-0002-4606-294X)
- Jarkko Ketolainen
- Marko Lehtonen (ORCID: https://orcid.org/0000-0002-5611-0466)
- Katja Pajula (ORCID: https://orcid.org/0000-0003-3455-7053)
- Eelis Komulainen
- Ossi Korhonen (ORCID: https://orcid.org/0000-0001-6878-8621)
- Tuomas Kilpeläinen (ORCID: https://orcid.org/0000-0003-4712-7589)
- Mpho Kotlolo
Institutions
- Tshwane University of Technology (ZA)
- University of Eastern Finland (FI)
- Eastern Finland Laboratory Center (FI)
Publication Details
- Journal
- European Journal of Pharmaceutical Sciences
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.ejps.2025.107299
- Citations
- 1
- Primary Topic
- Pharmaceutical studies and practices
- Type
- article
- Field-Weighted Citation Impact
- 3.49