PREVALÊNCIA DA SÍNDROME DE EDWARDS NO BRASIL DE 2014 A 2023 ATRAVÉS DO DATASUS

ABSTRACT Edwards syndrome, also known as trisomy 18, is characterized by aneuploidy, a numerical chromosomal alteration that results in autosomal trisomy of chromosome 18. The vast majority of fetuses with this trisomy result in miscarriage, and its incidence is highest in females. This study aims to analyze the prevalence of Edwards syndrome in Brazil, according to data from the DATASUS system. This descriptive study analyzes data from the Brazilian Unified Health System (DATASUS) information department on live births of Edwards syndrome in Brazil, including the region of prevalence, gestational age, type of pregnancy, and race/color, between 2014 and 2023. The study indicates that the prevalence of live births is very low; the vast majority of cases occur in the south and southeast regions of Brazil, with a predominance of white individuals, cesarean sections, singleton pregnancies, and 32- to 41-week gestation. The text concludes that despite the low survival rate, cases and their characteristics do exist, and that further research is crucial to better understand the factors that influence the syndrome. Keywords: DATASUS. Prevalence. Edwards Syndrome.