Branched-Chain Amino Acids and Testosterone in Older Adults With Type 2 Diabetes: Cross-Sectional and Longitudinal Findings From a Post Hoc Analysis of an Amino Acid Supplementation Trial
Cross-sectional associations between serum BCAA and testosterone levels in older adults with T2D were not observed longitudinally and may not reflect direct relationships, but rather influenced by insulin resistance or SHBG levels related to body composition. As this was an exploratory analysis with a small sample size, the results should be interpreted with caution.
Authors
- Yoshinori Osaki (ORCID: https://orcid.org/0000-0003-1425-7790)
- Kosuke Kojo (ORCID: https://orcid.org/0000-0002-6875-0874)
- Motohiro Sekiya
- Hitoshi Shimano (ORCID: https://orcid.org/0000-0002-5562-5572)
- Bryan J. Mathis (ORCID: https://orcid.org/0000-0002-9879-8289)
- Yasuhiro Suzuki
- Hiroyuki Nishiyama (ORCID: https://orcid.org/0000-0001-7423-596X)
- Erika Matsuda (ORCID: https://orcid.org/0000-0002-9465-3007)
- Hiroaki Suzuki (ORCID: https://orcid.org/0000-0003-0442-3687)
- Takaaki Matsuda (ORCID: https://orcid.org/0009-0000-8780-8536)
Institutions
- Jissen Women's University (JP)
- University of Tsukuba (JP)
- University of Tsukuba Hospital (JP)
Publication Details
- Journal
- Cureus
- Published
- 2025-09-12
- DOI
- https://doi.org/10.7759/cureus.92180
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 0.00