NET degradation attenuates ricin-induced acute lung injury and protects mice from ARDS
These findings demonstrate for the first time that NETosis plays a significant pathological role in ricin-induced lung injury. Moreover, they underscore the therapeutic potential of combining advanced NET-degrading agents, specifically PRX-119, an advanced DNAse I under development, with toxin-neutralizing antibodies as a promising strategy to reduce acute lung damage and enhance clinical outcomes.
Authors
- Anita Sapoznikov (ORCID: https://orcid.org/0000-0002-2543-7837)
- Yentl Evgy
- Ilya Ruderfer
- Liat Fux
- Yakir Nataf
- Reut Falach
- Yoav Gal
- Noam Erez (ORCID: https://orcid.org/0000-0001-5241-8028)
- Alon Ben-David
- Rachel Mizrachi
- Yael Hayon
- Shay Zamin
- Rachel Pessah
Institutions
- Israel Institute for Biological Research (IL)
- Protalix BioTherapeutics (Israel) (IL)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s10020-025-01370-8
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00