Accelerated biological aging mediates the associations of stress hyperglycemia ratio (SHR) with mortality in type 2 diabetes and obesity (diabesity)
Both SHR and accelerated biological aging independently predict higher all-cause, CVD, and cancer mortality in patients with type 2 diabetes and obesity. Furthermore, KDMAgeAccel could significantly mediates these associations, while PhenoAgeAccel could potentially suppress the direct effect of SHR on all-cause and CVD mortality, and exacerbate SHR's direct effect on cancer mortality. Interventions targeting both stress hyperglycemia and aging-related pathways may reduce mortality risks in patients with type 2 diabetes and obesity.
Authors
- Jinling Xu (ORCID: https://orcid.org/0000-0003-4206-6617)
- Hui Zhou (ORCID: https://orcid.org/0000-0002-2537-3060)
- Zhongjing Wang (ORCID: https://orcid.org/0000-0002-8684-1200)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Central Hospital of Wuhan (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s12933-025-02931-1
- Citations
- 3
- Primary Topic
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- National Natural Science Foundation of China
- Huazhong University of Science and Technology
- Tongji University
- Tongji Medical College, Huazhong University of Science and Technology