Cholecystokinin ameliorates cognitive impairment via inhibiting microglia phagocytosis of excitatory synapses in sepsis-associated encephalopathy mice
CCK may alleviate cognitive impairment by inhibiting microglia C1q-mediated phagocytosis of excitatory synapses, suggesting that both CCK drugs and specific activation of CCK-positive neurons are potential treatments for SAE.
Authors
- Jingshu Hong (ORCID: https://orcid.org/0000-0003-2875-4042)
- Luhua Chen
- Kaixi Liu
- Lei Chen (ORCID: https://orcid.org/0000-0001-6704-4313)
- Yubo Gao
- Zhen Li (ORCID: https://orcid.org/0000-0001-8037-4245)
- Qian Wang (ORCID: https://orcid.org/0000-0001-5504-0008)
- Yitong Li (ORCID: https://orcid.org/0000-0003-1992-7861)
- Taotao Liu (ORCID: https://orcid.org/0000-0001-9467-920X)
- Xiangyang Guo (ORCID: https://orcid.org/0000-0002-3987-4499)
- Zhengqian Li
- Ailian Du (ORCID: https://orcid.org/0009-0007-8962-5312)
- Jie Wang (ORCID: https://orcid.org/0000-0002-2997-3450)
- Guangxi Piao
Institutions
- Hong Kong Polytechnic University (HK)
- Peking University (CN)
- People 's Hospital of Jilin Province (CN)
- Hubei University of Arts and Science (CN)
- Ningxia Medical University (CN)
- Songjiang District Central Hospital (CN)
- Peking University Third Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s12974-025-03554-9
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Peking University
- Peking University Third Hospital