MSCs-EXOs containing miR-21a-5p promoted cell proliferation in the rat retinal Müller cell rMC-1 via targeting LATS1
Our research proved that MSCs-EXOs containing miR-21a-5p increased the expression of YAP via targeting LATS1, and ultimately promoted the cell proliferation in rMC-1. Our current study clarified the molecular mechanism of MSCs-EXOs-regulated cell proliferation and function protection in rMC-1 and provided a novel strategy for the treatment of DR.
Authors
- Ying Wang (ORCID: https://orcid.org/0009-0009-1586-7946)
- Longfeng Deng
Institutions
- Central South University (CN)
- He Eye Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s13287-025-04639-1
- Citations
- 1
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 1.15