Emulation of a Target Trial of Antihypertensive Medications on Weight Change
We observed small differences in weight change across antihypertensive medications, with lisinopril leading to weight loss and metoprolol and propranolol to modest weight gain. Clinicians should consider potential weight gain when selecting antihypertensive medications.
Authors
- Jason P. Block (ORCID: https://orcid.org/0000-0001-7660-9064)
- David M. Janicke (ORCID: https://orcid.org/0000-0002-8493-610X)
- L. Charles Bailey (ORCID: https://orcid.org/0000-0002-8967-0662)
- Matthew F. Daley (ORCID: https://orcid.org/0000-0003-1309-4096)
- William J. Heerman (ORCID: https://orcid.org/0000-0002-9706-6860)
- Jessica G. Young (ORCID: https://orcid.org/0000-0002-2758-6932)
- Carlos Maeztu (ORCID: https://orcid.org/0000-0003-3212-1651)
- Joshua Petimar (ORCID: https://orcid.org/0000-0002-3025-5931)
- Kristina H. Lewis (ORCID: https://orcid.org/0000-0002-4921-7230)
- Pi‐I D. Lin (ORCID: https://orcid.org/0000-0003-3564-4255)
- Yu Han (ORCID: https://orcid.org/0000-0002-4753-526X)
- Sheryl L. Rifas‐Shiman
Institutions
- Children's Hospital of Philadelphia (US)
- Kaiser Permanente (US)
- Harvard University (US)
- University of Florida Health (US)
- Harvard Pilgrim Health Care (US)
- Wake Forest University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of General Internal Medicine
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1007/s11606-025-09787-x
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00