Revisiting Infusion Rate Limitations for Continuous Lumbar Plexus Blocks in Children and Adolescents with 0.2% Ropivacaine: A Pharmacokinetic Analysis
Pharmacokinetic modeling supports a bolus dose of 2 mg/kg, continuous infusion rates of ropivacaine at 0.4 mg · kg -1 · h -1 , and boluses every 6 h of 0.2 mg/kg in healthy children for lumbar plexus blockade for the first 24 h. After that, with currently accepted toxic thresholds for ropivacaine and PPX, consideration should be given to dosing strategies that reduce or eliminate infusions and support timed boluses.
Authors
- Katherine R. Gentry (ORCID: https://orcid.org/0000-0002-3978-6659)
- Thomas K. Henthorn (ORCID: https://orcid.org/0000-0002-8993-3936)
- Klane K. White
- Rani Sunder (ORCID: https://orcid.org/0000-0003-0486-9048)
- David M. Polaner (ORCID: https://orcid.org/0000-0001-8716-6289)
- Trevor Adams
- Corrie Anderson
Institutions
- Seattle Children's Hospital (US)
- Pediatrics and Genetics (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1097/aln.0000000000005775
- Citations
- 1
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 2.01