Fundamental prognostic difference of ATM gene mutation and deletion in newly diagnosed mantle cell lymphoma
ATM deletion is an important predictor of prognosis in MCL patients and should be routinely examined, especially in those with wild-type TP53. In contrast, an isolated ATM mutation may predict a better prognosis in the context of standard immunochemotherapy.
Authors
- Helena Urbánková (ORCID: https://orcid.org/0000-0002-8499-2961)
- Vít Procházka (ORCID: https://orcid.org/0000-0002-9861-3117)
- Eva Kriegová (ORCID: https://orcid.org/0000-0002-8969-4197)
- Tomáš Papajík (ORCID: https://orcid.org/0000-0001-5779-1139)
- Veronika Hanáčková (ORCID: https://orcid.org/0000-0001-7039-1770)
- Kristina Forsterová (ORCID: https://orcid.org/0000-0002-9119-081X)
- P Klener (ORCID: https://orcid.org/0000-0003-3721-3926)
- Jirina Manakova (ORCID: https://orcid.org/0000-0001-6931-5666)
- Diana Maláriková (ORCID: https://orcid.org/0000-0002-3493-7833)
- Anna Petráčková (ORCID: https://orcid.org/0000-0001-5210-4504)
- Michaela Vatolíková
- Patrik Flódr (ORCID: https://orcid.org/0000-0002-7982-5229)
- Adéla Berková (ORCID: https://orcid.org/0000-0002-7596-8038)
- Aleš Obr (ORCID: https://orcid.org/0000-0002-6758-3074)
- Zuzana Zemanová (ORCID: https://orcid.org/0000-0002-7538-6601)
- Marek Trněný (ORCID: https://orcid.org/0000-0002-6952-6073)
- Tomáš Fürst (ORCID: https://orcid.org/0000-0002-9426-4183)
- Andrea Hrušková
Institutions
- Charles University (CZ)
- University Hospital Olomouc (CZ)
- General University Hospital in Prague (CZ)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s10020-025-01376-2
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00