TNAP-induced CD47 membrane expression enhances TGF-β1 conversion in liver fibrosis
TNAP plays a critical regulatory role in TGF-β1-mediated liver fibrosis, probably by promoting the binding of CD47/TSP1. Targeting TNAP-mediated pathways may offer new therapeutic strategies for liver fibrosis.
Authors
- Qi Peng (ORCID: https://orcid.org/0009-0002-0452-6985)
- Hanqiu Zhang (ORCID: https://orcid.org/0009-0000-1765-1924)
- Yang Cheng (ORCID: https://orcid.org/0000-0002-5906-7694)
- Hao Chi (ORCID: https://orcid.org/0000-0002-5210-0770)
- Min Sun (ORCID: https://orcid.org/0000-0001-5883-0363)
- Wenkun Ma (ORCID: https://orcid.org/0000-0001-6196-7141)
- Xin Liang (ORCID: https://orcid.org/0000-0001-8420-5959)
- Liang Deng (ORCID: https://orcid.org/0000-0003-3628-6808)
- Fengling Peng
- Qiang Liu (ORCID: https://orcid.org/0000-0002-5451-4862)
- Lei Gao (ORCID: https://orcid.org/0000-0002-7972-2908)
- Jinqiu Zhao (ORCID: https://orcid.org/0000-0001-9745-3230)
- Yongguo Li (ORCID: https://orcid.org/0000-0002-9056-0057)
- Xiaoyu Wei (ORCID: https://orcid.org/0000-0001-9583-7601)
Institutions
- University of Hawaiʻi at Mānoa (US)
- Southwest Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Public Health Clinical Center of Chengdu (CN)
- Chongqing Medical University (CN)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1097/hc9.0000000000000781
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00