Plasma proteome correlations with liver stiffness in pediatric cholestasis implicate epithelial to mesenchymal transition
The plasma proteome is highly correlated in a disease-specific fashion with LSM in BA, A1AT, and ALGS. These correlations provide unique opportunities to identify biomarkers and focus attention on epithelial-to-mesenchymal transition in pediatric cholestasis.
Authors
- Evelyn Hsu (ORCID: https://orcid.org/0000-0003-4359-7102)
- M. Kyle Jensen
- Ronald J. Sokol (ORCID: https://orcid.org/0000-0001-7433-4095)
- Sridevi Devaraj (ORCID: https://orcid.org/0000-0001-9189-7914)
- Saul J. Karpen (ORCID: https://orcid.org/0000-0002-3379-7592)
- Arianna Barbetta (ORCID: https://orcid.org/0000-0001-7062-3236)
- Benjamin L. Shneider (ORCID: https://orcid.org/0000-0002-7208-0949)
- Rupa S. Kanchi
- Jean Pappas Molleston (ORCID: https://orcid.org/0000-0002-8708-0298)
- Simon Horslen (ORCID: https://orcid.org/0000-0001-5949-7363)
- Cristian Coarfa (ORCID: https://orcid.org/0000-0002-4183-4939)
- Sandra L. Grimm (ORCID: https://orcid.org/0000-0002-0682-3134)
- Jorge A. Bezerra (ORCID: https://orcid.org/0000-0001-9667-7742)
- Kasper S. Wang
- Kathleen M. Loomes (ORCID: https://orcid.org/0000-0002-1539-6672)
- Philip J. Lupo (ORCID: https://orcid.org/0000-0003-0978-5863)
- Rohit Kohli (ORCID: https://orcid.org/0000-0002-0198-7703)
- Philip J. Rosenthal (ORCID: https://orcid.org/0000-0002-7953-7622)
- Jeremy M. Schraw (ORCID: https://orcid.org/0000-0002-6674-9562)
- Juliet Emamaullee (ORCID: https://orcid.org/0000-0003-4238-3057)
- John C. Magee (ORCID: https://orcid.org/0000-0001-8416-7905)
- Alyssa Kriegmeier
Institutions
- Northwestern University (US)
- University of Southern California (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Baylor College of Medicine (US)
- Virginia Commonwealth University (US)
- University of Toronto (CA)
- University of Washington (US)
- University of Utah (US)
- University of Michigan (US)
- Children's Hospital Colorado (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1097/hc9.0000000000000796
- Citations
- 1
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01