Electroencephalogram prediction of propofol effects on neuromodulation in disorders of consciousness
Propofol-induced EEG modulation reflects etiology-dependent neural network vulnerabilities in DoC. TBI/CVA patients demonstrated entropy reduction linked to clinical recovery, suggesting transient network stabilization that may enhance SCS efficacy. In contrast, AIE-associated static dynamics imply irreversible structural damage. Integrated PSD/PE analysis holds prognostic potential for predicting SCS responsiveness, particularly in TBI/CVA cohorts. These findings advocate etiology-tailored neuromodulation strategies, though multicenter validation is imperative for clinical translation.
Authors
- Xiangyang Guo (ORCID: https://orcid.org/0000-0002-5694-2174)
- Zhenhu Liang
- Xuanling Chen (ORCID: https://orcid.org/0000-0002-4969-7465)
- Hongchuan Niu
- Jiapeng Huang (ORCID: https://orcid.org/0000-0002-4794-8400)
- Yuqian Wang (ORCID: https://orcid.org/0000-0003-4122-066X)
- Xuewei Qin (ORCID: https://orcid.org/0009-0009-5261-8287)
- Yuanli Zhao (ORCID: https://orcid.org/0000-0002-3263-6797)
- Lan Yao (ORCID: https://orcid.org/0000-0003-4356-6672)
- Kai Li (ORCID: https://orcid.org/0000-0002-9645-4896)
- Dongwei Li (ORCID: https://orcid.org/0000-0002-2432-8882)
- Zhilei Lan
- Xin Zhao (ORCID: https://orcid.org/0000-0002-5764-5630)
Institutions
- University of Louisville (US)
- Peking University (CN)
- Beijing Normal University (CN)
- Yanshan University (CN)
- Chinese Institute for Brain Research (CN)
- Institute of Electrical Engineering (CN)
- Peking University International Hospital (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fneur.2025.1637647
- Citations
- 2
- Primary Topic
- EEG and Brain-Computer Interfaces
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Ministry of Science and Technology of the People's Republic of China