Androgen receptor antagonist flutamide modulates estrogen receptor alpha expression in distinct regions of the hypospadiac rat penis
Future toxicological testing using new approach methodologies (NAMs) should consider androgen-estrogen balance and crosstalk in reproductive tissues as a mechanism of action.
Authors
- Marie Berg (ORCID: https://orcid.org/0000-0001-8358-6075)
- Marta Axelstad Petersen (ORCID: https://orcid.org/0000-0002-2375-0918)
- Monica Kam Draskau (ORCID: https://orcid.org/0000-0001-6986-5991)
- Andrew J. Pask (ORCID: https://orcid.org/0000-0002-1900-2263)
- Emilie Elmelund (ORCID: https://orcid.org/0000-0002-6624-728X)
- Terje Svingen (ORCID: https://orcid.org/0000-0003-4650-7651)
- J. Roy Black (ORCID: https://orcid.org/0000-0003-1872-9345)
- Ida W. Strand
Institutions
- The University of Melbourne (AU)
- AgriBio (AU)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fendo.2025.1654965
- Citations
- 4
- Primary Topic
- Urological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 7.35