Insights into the taxonomy and virulence-related genetic profiles in 97 Cupriavidus strains through comparative genomic analysis

This study addresses the taxonomic ambiguities arising from species complexes within 97 strains of Cupriavidus and proposes a genome-based taxonomic framework based on phylogenomic analysis. Beyond classification, we advance insights into the genus's pathogenesis by delineating virulence-related genetic profiles, including conserved and species-specific virulence factors, secretion systems, and antibiotic resistance genes. Collectively, this work establishes a genomic foundation for understanding phylogenetic relationships and a comparative framework to explore pathogenicity across 97 strains of Cupriavidus.