Functional studies on methylation of the promoter region of the NR2E1 gene regulating adipocytes in beef cattle
In the present investigation, we conducted methylation sequencing of the CpG island within the promoter region of the NR2E1 in three breeds of beef cattle, followed by a comprehensive co-analysis with transcriptome data. We further explored the influence of the NR2E1 on the proliferation, differentiation, apoptosis, and downstream signaling pathways in bovine adipocytes. The findings of this research serve as a foundational reference for advancing the molecular understanding of NR2E1 regulation in the context of bovine adipocyte biology.
Authors
- Hong Wei Chu (ORCID: https://orcid.org/0000-0002-8329-4803)
- Lupei Zhang (ORCID: https://orcid.org/0000-0001-7701-2331)
- Runjun Yang (ORCID: https://orcid.org/0000-0003-1401-4318)
- Dongzhi Wei (ORCID: https://orcid.org/0000-0003-3655-3937)
- Feng Lan (ORCID: https://orcid.org/0000-0002-1709-5179)
- Bei Cai
- Yuan Liu (ORCID: https://orcid.org/0000-0003-1655-7164)
- Yun Ma (ORCID: https://orcid.org/0000-0002-4672-3584)
- Fen Li (ORCID: https://orcid.org/0000-0002-8485-8965)
- Xue Bai (ORCID: https://orcid.org/0000-0002-2095-3242)
- Na Rina
Institutions
- Jilin University (CN)
- Ningxia University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Jilin Agricultural University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s12864-025-11886-2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China