Lymphomatosis cerebri presenting with rapidly progressive parkinsonism and Holmes tremor: a case report
This case illustrates that LC can manifest with atypical parkinsonian syndromes, such as parkinsonism and Holmes tremor. Clinicians should consider LC in the differential diagnosis of rapidly progressive movement disorders, especially when neuroimaging reveals diffuse non-enhancing white matter lesions such as leukodystrophy and demyelinating disease. Advanced imaging modalities such as ASL-MRI may facilitate early diagnosis and biopsy targeting.
Authors
- Yasushi Shimo (ORCID: https://orcid.org/0000-0003-1712-0845)
- Yasunori Sugiyama (ORCID: https://orcid.org/0000-0002-0520-3013)
- Takahiro Koinuma (ORCID: https://orcid.org/0000-0001-6602-7861)
- Tsuyoshi Furuya (ORCID: https://orcid.org/0009-0006-1178-6442)
- Hiroto Eguchi
- Asuka Nakajima (ORCID: https://orcid.org/0000-0001-6128-9029)
- Atsuhito Fuse
- T. Iguchi
Institutions
- Juntendo University Nerima Hospital (JP)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s12883-025-04426-8
- Citations
- 1
- Primary Topic
- CNS Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.39