Regulating osteogenic differentiation of bone marrow mesenchymal stem cells by mTORC1 signaling pathway inhibits bone defect repair in mice
The activated mTOR pathway during bone defect repair could inhibit the osteogenic ability of BMMSCs and hinder the bone healing process. Accordingly, regulating the activation of the mTOR pathway might promote the repair of bone defects.
Authors
- Qiguang Mai
- Zhuobin Huang (ORCID: https://orcid.org/0009-0005-2251-4146)
- Shicai Fan (ORCID: https://orcid.org/0000-0002-1993-6074)
- Jing Yang (ORCID: https://orcid.org/0000-0003-0773-494X)
- Ruanbing Li
- Siteng Li (ORCID: https://orcid.org/0000-0003-0103-1055)
- Cheng Yang (ORCID: https://orcid.org/0000-0002-7008-5965)
- Ziming Zhang (ORCID: https://orcid.org/0000-0002-5185-2081)
Institutions
- Nankai University (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Guangdong Hydropower Planning & Design Institute (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s13018-025-06249-2
- Citations
- 1
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Guangdong Medical Research Foundation
- National Key Research and Development Program of China