A computational investigation into the role of tRNAs encoded by Shigella phage Sf14

The most likely hypothesis explaining the presence of tRNAs in the Sf14 genome is the possession of an all-destructive infection phenotype, where genes encoding host tRNAs are degraded along with the genome and translation relies heavily or exclusively on the phage tRNAs. The differences in codon usage also suggest phage-encoded tRNAs specifically affect the production of late gene products.