HMGB1-mediated macrophage polarization to M2 phenotype promotes ureteral stricture: therapeutic potential of HMGB1 inhibitors
HMGB1 contributes to ureteral stricture by promoting macrophage polarization and fibroblast activation, leading to extracellular matrix accumulation and fibrosis. Glycyrrhizin effectively inhibits these processes and alleviates ureteral stricture, demonstrating its potential as a therapeutic agent for ureteral fibrosis. These findings provide a basis for further exploration of HMGB1-targeted therapies.
Authors
- Yingqing Liu
- Lingsong Tao (ORCID: https://orcid.org/0000-0002-3254-506X)
- Zongyao Hao (ORCID: https://orcid.org/0000-0003-3399-3689)
- Jie Zheng (ORCID: https://orcid.org/0000-0002-6623-6839)
- Yang Zhang (ORCID: https://orcid.org/0000-0002-1376-7273)
- Cheng Jung Li (ORCID: https://orcid.org/0000-0001-6110-8099)
Institutions
- Wannan Medical College (CN)
- Anhui Medical University (CN)
- Wuhu Fourth People Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s40001-025-03137-7
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00