Current states in understanding oligodendroglia-mediated neurological issues in neurofibromatosis type 1 (NF1)
Neurofibromatosis type 1 (NF1) is among the most common neurogenetic disorders and is associated with an increased risk of developing tumors in the nervous system. Additionally, up to 80% of patients with NF1 experience neurological complications, including deficits in attention, memory, and executive function. Significant effort has been dedicated to studying how NF1 mutations autonomously dysregulate neuronal function. Increasing evidence indicates that NF1 mutations also dysregulate the oligodendroglial lineage that contributes to neurological issues in NF1. Here, we summarize our current understanding of how NF1 mutations impact the oligodendroglial lineage homeostasis and plasticity. We also discuss gaps in knowledge, potential therapeutic strategies, and future directions.
Authors
- Benjamin E. Aghoghovwia (ORCID: https://orcid.org/0000-0001-5630-1361)
- Sabiha Bano
- Yuan Pan (ORCID: https://orcid.org/0000-0002-9465-8289)
- Khushboo Irshad (ORCID: https://orcid.org/0000-0002-1552-3686)
- Nicole M Brossier (ORCID: https://orcid.org/0000-0002-4197-6283)
- Chan Shen (ORCID: https://orcid.org/0000-0001-5463-3872)
- A. Marrero (ORCID: https://orcid.org/0009-0004-8881-4179)
- Samer Sharafaldin
- Nandini Shyamala
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Washington University in St. Louis (US)
- University of Houston (US)
Publication Details
- Journal
- Acta Neuropathologica Communications
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s40478-025-02119-4
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Cancer Prevention and Research Institute of Texas
- Andrew Sabin Family Foundation
- Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation
- University of Texas MD Anderson Cancer Center
- National Cancer Institute