Genetic risk and clinical implications of BRCA1 and BRCA2 mutations in Turkish triple-negative breast cancer patients
Turkish TNBC patients with BRCA1 + or BRCA2 + mutations exhibit unique clinical and familial characteristics, emphasizing the importance of genetic screening and familial risk evaluation in TNBC management. These findings underscore the clinical relevance of BRCA testing in TNBC patients for personalized screening and treatment strategies. Notably, this study provides the largest TNBC cohort (n = 485) reported from Türkiye, highlighting the significant role of BRCA1 in TNBC pathogenesis and offering a roadmap for individualized management.
Authors
- Özge Pasin (ORCID: https://orcid.org/0000-0001-6530-0942)
- Betül Çelik (ORCID: https://orcid.org/0000-0001-7923-275X)
- Özge Şükrüoğlu Erdoğan (ORCID: https://orcid.org/0000-0002-0893-1251)
- Zübeyde Yalnız Kayım (ORCID: https://orcid.org/0000-0002-3137-051X)
- Şeref Buğra Tunçer (ORCID: https://orcid.org/0000-0001-8023-3223)
- Seda Kılıç (ORCID: https://orcid.org/0000-0003-4417-4005)
- Merve Çiğdem Özgel (ORCID: https://orcid.org/0000-0002-3014-0843)
Institutions
- Sağlık Bilimleri Üniversitesi (TR)
- Cancer Genetics (United States) (US)
- Istanbul University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1007/s12672-025-03470-7
- Citations
- 1
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.82