Biomarkers For Early Alzheimer's Disease Diagnosis

Alzheimer's disease (AD) is a progressive neurological disorder characterized by memory loss, cognitive decline, and neurodegeneration. Early diagnosis through biomarkers is crucial for improving treatment outcomes and managing the disease. This review highlights invasive and non-invasive biomarkers for AD diagnosis which includes cerebrospinal fluid, blood-based, exosomal, and fluid-based biomarkers. Neuroimaging techniques, such as structural MRI and functional imaging, are also discussed. Recent advancements in blood-based biomarker technology and emerging AI and machine learning techniques offer promising avenues for early AD diagnosis. Future non-invasive diagnostic tools which includes wearable sensors may aid in early detection and personalized treatments.

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Publication Details

Journal
Nepal Journal of Neuroscience
Published
2025-09-29
DOI
https://doi.org/10.3126/njn.v22i2.80007
Primary Topic
Health, Environment, Cognitive Aging
Type
article
Field-Weighted Citation Impact
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article

Biomarkers For Early Alzheimer's Disease Diagnosis

Unsa Saleem
Nepal Journal of Neuroscience
Health, Environment, Cognitive Aging
article

Biomarkers For Early Alzheimer's Disease Diagnosis

Unsa Saleem
article en

Abstract

Alzheimer's disease (AD) is a progressive neurological disorder characterized by memory loss, cognitive decline, and neurodegeneration. Early diagnosis through biomarkers is crucial for improving treatment outcomes and managing the disease. This review highlights invasive and non-invasive biomarkers for AD diagnosis which includes cerebrospinal fluid, blood-based, exosomal, and fluid-based biomarkers. Neuroimaging techniques, such as structural MRI and functional imaging, are also discussed. Recent advancements in blood-based biomarker technology and emerging AI and machine learning techniques offer promising avenues for early AD diagnosis. Future non-invasive diagnostic tools which includes wearable sensors may aid in early detection and personalized treatments.

Nepal Journal of NeuroscienceVol. 22(2)
Liaquat University of Medical & Health Sciences (PK)
Openalex Percentile: Top 65%
Health, Environment, Cognitive Aging
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