Genetic Association of Primary Lung Cancer With Urological Cancers: A Bidirectional Mendelian Randomization Study and <scp>SEER</scp> Database Validation
The MR study identified genetic associations between LC and UCs, revealing an elevated risk of SPC-RCC after primary LC (PLC), particularly LUAD. This study lays a foundation for SPC-RCC prevention after PLC, indicating the necessity of enhanced surveillance of PLC patients in clinical practice and further research into the shared biological pathways to provide innovative therapeutic alternatives.
Authors
- Zhiyu Dai (ORCID: https://orcid.org/0000-0002-2945-7923)
- Kezhi Liu (ORCID: https://orcid.org/0000-0003-4515-4209)
- Zhilong Ai (ORCID: https://orcid.org/0000-0002-5264-8875)
- Xiaohan Jin (ORCID: https://orcid.org/0000-0003-1982-8345)
- Yinghan Wang (ORCID: https://orcid.org/0000-0002-3737-3535)
- Cun‐Jing Zheng (ORCID: https://orcid.org/0000-0002-0836-6598)
- Ling Xia (ORCID: https://orcid.org/0000-0002-1937-9693)
- Ning Su (ORCID: https://orcid.org/0000-0002-2799-133X)
- Hui Zhou (ORCID: https://orcid.org/0000-0002-6318-894X)
- Jing Zhang (ORCID: https://orcid.org/0000-0003-2265-565X)
- Zhenhua Chen (ORCID: https://orcid.org/0000-0002-5195-2234)
- Zihao Feng (ORCID: https://orcid.org/0009-0008-0015-6837)
- Zhenwei Li (ORCID: https://orcid.org/0000-0001-8550-8513)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Chest Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1002/cam4.71272
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00