PGC1A Restores Mitochondrial Health to Attenuate EMT During Lens Epithelial Fibrosis via Regulating TFAM
PGC1A safeguards LECs against EMT by restoring TFAM-mediated mitochondrial energy metabolism under TGFβ2 stress, offering potential targets for the treatment of lens epithelial fibrosis.
Authors
- Shan Huang (ORCID: https://orcid.org/0000-0001-8492-9658)
- Jieping Chen (ORCID: https://orcid.org/0000-0001-9666-2911)
- Yizhi Liu (ORCID: https://orcid.org/0000-0003-4108-9593)
- Jiani Wang (ORCID: https://orcid.org/0000-0002-0869-3468)
- Mi Ni Huang (ORCID: https://orcid.org/0000-0002-7669-7364)
- Baoxin Chen (ORCID: https://orcid.org/0000-0002-0205-8850)
- P. Z. Jiang
- Jingqi Huang
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1167/iovs.66.12.67
- Citations
- 2
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 1.61