Primary Lateral Sclerosis Natural History Study: <scp>Primary Lateral Sclerosis Functional Rating Scale</scp> and Other Outcomes Assessment
In PLS, the rate of functional decline, as measured by the PLSFRS total score, is faster during the early phase of the disease. Neurofilament light might serve as a prognostic biomarker in PLS. ANN NEUROL 2026;99:418-428.
Authors
- Terry Heiman‐Patterson (ORCID: https://orcid.org/0000-0002-9910-1041)
- Joseph Americo Fernandes
- Ikjae Lee (ORCID: https://orcid.org/0000-0003-0537-9622)
- Sabrina Paganoni (ORCID: https://orcid.org/0000-0003-0505-1168)
- Wendy Johnston (ORCID: https://orcid.org/0000-0002-4330-5563)
- Christina Fournier (ORCID: https://orcid.org/0000-0002-1561-2419)
- Matthew Harms (ORCID: https://orcid.org/0000-0002-3395-1633)
- Nicholas J. Maragakis (ORCID: https://orcid.org/0000-0002-7311-9614)
- Ying Kuen Cheung
- Zachary Simmons (ORCID: https://orcid.org/0000-0001-8574-5332)
- Kelly Gwathmey (ORCID: https://orcid.org/0000-0002-7589-8826)
- Frank Diaz (ORCID: https://orcid.org/0000-0003-3526-1852)
- Ghazala Hayat (ORCID: https://orcid.org/0000-0003-4159-6966)
- Lorne Zinman (ORCID: https://orcid.org/0000-0002-8096-8366)
- Björn Oskarsson (ORCID: https://orcid.org/0000-0002-1725-9866)
- Daragh Heitzman
- David Walk (ORCID: https://orcid.org/0000-0001-7941-1993)
- Omar Jawdat
- Senda Ajroud‐Driss (ORCID: https://orcid.org/0000-0001-7627-425X)
- Katherine M. Burke (ORCID: https://orcid.org/0000-0002-5820-5880)
- Grace E. Jang (ORCID: https://orcid.org/0009-0002-8051-7052)
- Hiroshi Mitsumoto (ORCID: https://orcid.org/0000-0001-6259-8923)
- Yaz Y. Kisanuki
- James P. Wymer (ORCID: https://orcid.org/0000-0003-0809-2977)
- RN ByoungSook Yun
- Eric J. Sorenson (ORCID: https://orcid.org/0009-0000-7773-7754)
- Lauren Elman (ORCID: https://orcid.org/0000-0003-4706-950X)
- Regina M. Santella (ORCID: https://orcid.org/0000-0003-0823-6221)
- Michael Pulley (ORCID: https://orcid.org/0000-0003-1879-725X)
- Stephen A. Goutman (ORCID: https://orcid.org/0000-0001-8780-6637)
- Benjamin N. Hoover
- Jaimin Shah (ORCID: https://orcid.org/0000-0003-4379-0666)
- Alexander Sherman (ORCID: https://orcid.org/0000-0001-5089-7491)
- Ali A. Habib (ORCID: https://orcid.org/0000-0003-3432-9747)
- Edward J. Kasarskis
- Stephen N. Scelsa (ORCID: https://orcid.org/0000-0002-1239-7899)
- Christen L. Shoesmith (ORCID: https://orcid.org/0000-0003-2472-3804)
- Mary Kay Floeter
- Catherine Lomen‐Hoerth (ORCID: https://orcid.org/0000-0003-3320-5996)
Institutions
- Northwestern University (US)
- Western University (CA)
- Cedars-Sinai Medical Center (US)
- National Institutes of Health (US)
- University of Minnesota (US)
- Pennsylvania State University (US)
- Sunnybrook Health Science Centre (CA)
- Mayo Clinic (US)
- Harvard University (US)
- University of Kentucky (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of Alberta (CA)
- MGH Institute of Health Professions (US)
- University of California, San Francisco (US)
- Virginia Commonwealth University (US)
- Saint Louis University (ES)
- University of California, Irvine (US)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
- Spaulding Rehabilitation Hospital (US)
- Johns Hopkins Medicine (US)
- Jacksonville College (US)
- Health Sciences Centre (CA)
- The Ohio State University Wexner Medical Center (US)
- University of Florida (US)
- Massachusetts General Hospital (US)
- University of California, Irvine Medical Center (US)
- University of Kansas Medical Center (US)
- Texas Neurology (US)
- Mayo Clinic in Florida (US)
- Saint Louis University (US)
- University of Nebraska Medical Center (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Penn State Milton S. Hershey Medical Center (US)
- Temple University (US)
- Florida College (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1002/ana.78056
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00