[<i>ANXA2</i> and NF<b>-</b>κB positive feedback loop promotes high glucose<b>-</b>induced pyroptosis in renal tubular epithelial cells].
<i>ANXA2</i> and NF-κB form a positive feedback loop that sustains <i>NLRP3</i> inflammasome activation, promotes pyroptosis pathway activation, and aggravates high glucose-induced renal tubular epithelial cell injury. Targeting <i>ANXA2</i> or blocking its interaction with p65 may be a novel strategy to slow DKD progression.
Authors
- Yang Luo (ORCID: https://orcid.org/0000-0001-7385-6166)
- Wenbin Tang (ORCID: https://orcid.org/0000-0002-0637-9125)
- Jiayi Yang (ORCID: https://orcid.org/0000-0003-2372-5197)
- Zhiyang Zhu (ORCID: https://orcid.org/0000-0001-9076-7288)
Institutions
- Central South University (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-06-28
- DOI
- https://doi.org/10.11817/j.issn.1672-7347.2025.250305
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article