Patients with osteoporosis: Treatment with zoledronic acid instead of alendronic acid is associated with a higher risk of ischemic stroke - A real-world global study

Zoledronic acid was associated with an increased ischemic stroke risk compared to alendronic acid in the general population, in women, and in patients without pre-existing atrial fibrillation or aortic atherosclerosis. Therefore, we recommend long-term follow-up and strict management of stroke risk factors in these relatively vulnerable populations.