Trajectories of depressive symptoms, metabolic syndrome, inflammation, and cardiometabolic diseases: A longitudinal Bayesian network approach
The findings traced a pathway linking specific energy-related depressive symptoms (e.g. low energy, appetite/weight oscillations and hypersomnia) to inflammation, dyslipidaemia and diabetes. Depressive symptoms and biological markers connected in this identified pathway may provide a valuable target to reduce cardiometabolic risk related to depression.
Authors
- Bennard Doornbos (ORCID: https://orcid.org/0000-0002-5013-3501)
- Arja O. Rydin (ORCID: https://orcid.org/0000-0002-5525-3350)
- Yuri Milaneschi (ORCID: https://orcid.org/0000-0002-3697-6617)
- Brenda W.J.H. Penninx (ORCID: https://orcid.org/0000-0001-7779-9672)
- Rick Quax (ORCID: https://orcid.org/0000-0002-0299-0074)
- Femke Lamers (ORCID: https://orcid.org/0000-0003-4344-5766)
- Angela Koloi (ORCID: https://orcid.org/0009-0001-8197-3749)
- Noah van de Bunt
Institutions
- University of Ioannina (GR)
- Lentis (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.bbi.2025.106120
- Citations
- 2
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- European Commission
- Universiteit Leiden
- Vrije Universiteit Amsterdam
- Rivierduinen
- GGZ Friesland
- GGZ Drenthe