10° compared to 22° celsius cold fluid bolus does not affect hemostasis in healthy adults – A randomized crossover trial
Administration of a bolus of Ringer's lactate at 10 °C compared to 22 °C resulted in a minor prolongation of clotting time after 30 min as assessed by thromboelastometry and had minimal impact on hemostasis. Fibrinogen was slightly elevated after 30 min. We conclude that administering 1000 mL of cold fluids does not notably affect hemostasis and is considered safe in healthy adults.
Authors
- Pernille Just Vinholt (ORCID: https://orcid.org/0000-0002-2035-0169)
- Casper Nielsen
- Lasse Paludan Bentsen (ORCID: https://orcid.org/0000-0001-6809-3141)
- Mette Løkke
- Mette Rahbek Kristensen (ORCID: https://orcid.org/0000-0001-5428-3163)
- Line Emilie Laugesen
- Mikkel Brabrand (ORCID: https://orcid.org/0000-0002-3340-8251)
- Camilla Schade Hansen (ORCID: https://orcid.org/0000-0002-2207-8883)
- Peter Biesenbach (ORCID: https://orcid.org/0000-0003-4969-2186)
- Angela Dahlberg (ORCID: https://orcid.org/0009-0009-9401-6954)
Institutions
- Chinese University of Hong Kong (HK)
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- Region of Southern Denmark (DK)
- Hospital South West Jutland (DK)
Publication Details
- Journal
- Journal of Thermal Biology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.jtherbio.2025.104276
- Primary Topic
- Thermoregulation and physiological responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00