[Itaconic acid alleviates macrophage PANoptosis in sepsis<b>-</b>associated acute lung injury via inhibiting ninjurin<b>-</b>1<b>-</b>mediated plasma membrane rupture].
Itaconic acid may alleviate macrophage PANoptosis in S-ALI by inhibiting NINJ1-mediated plasma membrane rupture. Targeting NINJ1 or enhancing itaconate pathways may offer a novel therapeutic strategy for S-ALI.
Authors
- Shaokun Liu (ORCID: https://orcid.org/0000-0002-9839-2342)
- M. Chen
- Xiaohua Tan (ORCID: https://orcid.org/0000-0003-0079-8254)
- Wenjing Zhong (ORCID: https://orcid.org/0000-0002-9045-8706)
- Han-Xi Sha
- Liying Liang
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-06-28
- DOI
- https://doi.org/10.11817/j.issn.1672-7347.2025.250283
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article