Effect of retinoic acid on delayed encephalopathy after acute carbon monoxide poisoning: Role of the lncRNA <i>SNHG15</i>/<i>LINGO</i><i>-</i><i>1</i>/BDNF/TrkB axis.
RA alleviates CO-induced apoptosis of hippocampal neurons and oligodendrocytes, thereby reducing central nervous system injury and exerting neuroprotective effects. LncRNA <i>SNHG15</i> and <i>LINGO-1</i> are key molecules mediating RA-induced inhibition of neuronal apoptosis and are associated with the BDNF/TrkB pathway. These findings provide a theoretical framework for optimizing the clinical treatment of DEACMP and lay an experimental foundation for elucidating its molecular mechanisms.
Authors
- Xu‐Feng Huang (ORCID: https://orcid.org/0000-0002-5895-2253)
- Zhengrong Peng (ORCID: https://orcid.org/0000-0003-3048-4344)
- Sue Wang (ORCID: https://orcid.org/0000-0003-4587-429X)
- Fangling Huang (ORCID: https://orcid.org/0000-0002-6097-5024)
- Sufen Bai
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-06-28
- DOI
- https://doi.org/10.11817/j.issn.1672-7347.2025.240318
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- article
- Field-Weighted Citation Impact
- 0.00