Multidimensional analysis of costs and outcomes in a Colombian cohort of pediatric <i>Streptococcus pneumoniae</i> meningitis cases (2017–2022)

<i>Streptococcus pneumoniae</i> meningitis poses a significant public health challenge, imposing substantial burdens on healthcare systems. This study analyzed the costs and outcomes of pneumococcal meningitis in a Colombian cohort of children from 2017 to 2022, using correspondence analysis and cost assessment to explore the impact of vaccination. A retrospective cohort study was conducted, analyzing children under 18 years diagnosed with pneumococcal meningitis. A total of 55 cases were analyzed in this cohort study, which, while representative of confirmed cases in the country, reflects the rarity of the disease and poses statistical limitations. Direct healthcare costs were calculated in 2023 USD, and data were assessed using cluster and multiple correspondence analyses (MCA) to evaluate relationships between vaccination status, serotypes, clinical outcomes, and costs. The MCA revealed two main dimensions that collectively explained 31.2% of the total variance. Median direct healthcare costs were ~$2,900 (range ~$500-$21,000), with ICU admission as the primary cost driver. PCV13 vaccination correlated with lower overall patient costs and better clinical outcomes. MCA revealed clustering of vaccinated patients with favorable outcomes and reduced costs, while unvaccinated patients aligned with severe outcomes and higher expenses. This study explores the clinical and economic impact of pneumococcal meningitis in pediatric patients, highlighting the potential protective role of PCV13 vaccination. MCA provided an exploratory framework for examining relationships between vaccination status, serotypes, costs, and outcomes.

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Publication Details

Journal
Human Vaccines & Immunotherapeutics
Published
2025-09-29
DOI
https://doi.org/10.1080/21645515.2025.2562738
Primary Topic
Pneumonia and Respiratory Infections
Type
article
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article

Multidimensional analysis of costs and outcomes in a Colombian cohort of pediatric Streptococcus pneumoniae meningitis cases (2017–2022)

M. Suárez, Bogar O. Araujo-Montoya, Juan Pablo Rojas Hernández, Wilfrido Coronell-Rodríguez et al.
Human Vaccines & Immunotherapeutics
Pneumonia and Respiratory Infections
article

Multidimensional analysis of costs and outcomes in a Colombian cohort of pediatric Streptococcus pneumoniae meningitis cases (2017–2022)

M. Suárez, Bogar O. Araujo-Montoya, Juan Pablo Rojas Hernández, Wilfrido Coronell-Rodríguez, Anita Montañez Ayala, Germán Camacho‐Moreno, N. Rodríguez, Eugenia Gallo, Vivian Marcela Moreno, Alina Acosta Cedeño, Jaime Patiño, Aura Lucía Leal, Martha I. Álvarez-Olmos, Juan Pablo Londoño-Ruiz, Sandra Jaqueline Beltrán-Higuera, Ivan Felipe Gutiérrez-Tobar, Pío López, Catalina Arango Ferreira, Pablo Vásquez‐Hoyos, Eduardo López‐Medina, Otávio Augusto de Oliveira Franco, Ana Cristina Mariño, Esther Rocio Barrero Barreto, Fabio Enrique Espinosa Acuña, Mónica Rosa Trujillo Honeysberg
article en

Abstract

<i>Streptococcus pneumoniae</i> meningitis poses a significant public health challenge, imposing substantial burdens on healthcare systems. This study analyzed the costs and outcomes of pneumococcal meningitis in a Colombian cohort of children from 2017 to 2022, using correspondence analysis and cost assessment to explore the impact of vaccination. A retrospective cohort study was conducted, analyzing children under 18 years diagnosed with pneumococcal meningitis. A total of 55 cases were analyzed in this cohort study, which, while representative of confirmed cases in the country, reflects the rarity of the disease and poses statistical limitations. Direct healthcare costs were calculated in 2023 USD, and data were assessed using cluster and multiple correspondence analyses (MCA) to evaluate relationships between vaccination status, serotypes, clinical outcomes, and costs. The MCA revealed two main dimensions that collectively explained 31.2% of the total variance. Median direct healthcare costs were ~$2,900 (range ~$500-$21,000), with ICU admission as the primary cost driver. PCV13 vaccination correlated with lower overall patient costs and better clinical outcomes. MCA revealed clustering of vaccinated patients with favorable outcomes and reduced costs, while unvaccinated patients aligned with severe outcomes and higher expenses. This study explores the clinical and economic impact of pneumococcal meningitis in pediatric patients, highlighting the potential protective role of PCV13 vaccination. MCA provided an exploratory framework for examining relationships between vaccination status, serotypes, costs, and outcomes.

Human Vaccines & ImmunotherapeuticsVol. 21(1)
Toyobo (Japan) (JP), University of Cartagena (CO), Misericordia Community Hospital (CA), Hospital Universitario de San Vicente Fundación (CO), Universidad Nacional de Colombia (CO), Hospital Universitario del Valle ESE (CO), Departamento de Epidemiología (GT), Clínica Girona (ES), Infant (IE), Universidad de Oriente (SV), Hospital Militar Central (CO), Hospital Pablo Tobon Uribe (CO), Hospital Quirónsalud Barcelona (ES), Clínica Santa María (CO), Institute of Cardiology (CO), Departamento de Salud (ES), Centro Peruano de Estudios Sociales (PE), Clínica CES (CO), Colciencias (CO), Hospital Universitario San Ignacio (CO), Hospital Universitario San Rafael (ES), Hospital Universitario Infantil San José (CO), Misericordia University (US), Centro de Estudios Científicos (CL), Universidad Libre de Colombia (CO)
Openalex Percentile: Top 64%
Pneumonia and Respiratory Infections
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