PARP-1 rs1136410 Polymorphism and Gastrointestinal Cancer Risk: A Meta-Analysis of Cancer-Type and Ethnic-Specific Associations
The <i>PARP-1</i> rs1136410 polymorphism is associated with elevated GC risk but not CRC, with ethnicity-dependent effects suggesting differential genetic susceptibility. These findings highlight the importance of considering population-specific genetic backgrounds in gastrointestinal cancer risk assessment, prevention, and precision medicine strategies.
Authors
- Seyed Masoud HaghighiKian (ORCID: https://orcid.org/0000-0003-4674-5764)
- Bahareh Mehdikhani (ORCID: https://orcid.org/0000-0002-7487-9922)
- Samira Soleymani
- Hossein Neámatzadeh (ORCID: https://orcid.org/0000-0003-1031-9288)
- Mohammad Hossein Antikchi (ORCID: https://orcid.org/0000-0001-7781-5740)
- Alireza Nezameslami
- Ahmad Shirinzadeh-Dastgiri (ORCID: https://orcid.org/0009-0005-2152-5425)
- Amirhossein Rahmani (ORCID: https://orcid.org/0000-0002-1771-3053)
- Mohammad Vakili-Ojarood (ORCID: https://orcid.org/0000-0002-4396-5828)
- Amirhosein Naseri (ORCID: https://orcid.org/0000-0001-8548-1330)
- Rezvan Nezameslami
- Mehdi Khosravi (ORCID: https://orcid.org/0000-0002-4852-5733)
Institutions
- Iran University of Medical Sciences (IR)
- Shahid Sadoughi University of Medical Sciences and Health Services (IR)
- Ardabil University of Medical Sciences (IR)
- Iranshahr University (IR)
- Farabi Hospital (IR)
- Imam Reza Hospital (IR)
- Islamic Azad University, Yazd (IR)
- Imam Hossein Hospital (IR)
Publication Details
- Journal
- Medeniyet Medical Journal
- Published
- 2025-09-29
- DOI
- https://doi.org/10.4274/mmj.galenos.2025.72708
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00