The Interplay Between Cardiac Metabolism and Tumor Cell Biology: Metabolic Remodeling

Abstract Purpose of the Review In this review article, we present recent conceptual advances in understanding metabolic reprogramming in cancer and CVD and discuss how the assessment of metabolic features using provides opportunities for diagnosis and therapy in cardio-oncology patients. Recent Findings Cardiovascular disease (CVD) and cancer are the two leading causes of morbidity and mortality in the world. Cancer and CVD are intertwined by metabolic changes that promote tumor progression and increase the risk for cardiovascular sequelae. Understanding these interactions has become a focus in “cardio-oncology” to unravel this complex relationship. Several studies demonstrate the consequences of cardiac-specific loss of metabolic activities that can exacerbate cancer-therapy-related toxicities or increase disease progression. Summary Incorporating multi-omics studies with translational models will produce new insights into the relationship between cancer cells and cardiomyocytes at different disease and metabolic states and allow targeted treatments.