Single-cell transcriptomic analyses provide insights into SPP1+ TAM-mediated immune suppression and CD8+ T cell dysfunction in lung cancer
Our findings characterize the immunological environment of both primary and metastatic lung cancer, highlighting SPP1-mediated immune suppression as a potential therapeutic target to restore T cell responses. Preclinical data demonstrate that Anti-SPP1 antibodies can reverse T cell exhaustion and enhance immune responses in lung cancer.
Authors
- Qitai Zhao (ORCID: https://orcid.org/0000-0003-4023-2060)
- M. James You (ORCID: https://orcid.org/0000-0002-9111-8068)
- Jinyan Liu
- Yi Zhang (ORCID: https://orcid.org/0000-0001-8373-017X)
- Tengyue Zhang (ORCID: https://orcid.org/0000-0003-0037-7345)
- Rahma Taher Almgrami
Institutions
- Zhengzhou University (CN)
- Henan Academy of Sciences (CN)
- Henan Cancer Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1007/s00262-025-04180-3
- Citations
- 6
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- National Natural Science Foundation of China