Unraveling the Immunomodulatory Mechanisms of Quan-du-zhong Capsule in Diabetic Kidney Disease via Integrated Network Pharmacology and Experimental Validation

This study illustrates the mechanism by which QDZ upregulates FOS expression and modulates the MAPK signaling pathway, thereby regulating immune cell function in DKD. These findings provide novel insights to inform future research and development of QDZ-based DKD therapies.

Authors

Bo Xie (ORCID: https://orcid.org/0000-0002-6016-6008)
Xunli Xiao (ORCID: https://orcid.org/0000-0002-6402-2220)
Zunyou Wu
Cong Zhou (ORCID: https://orcid.org/0000-0002-1526-1452)
Jun Xiao (ORCID: https://orcid.org/0000-0002-2222-967X)
Guohua Liu (ORCID: https://orcid.org/0000-0003-3164-3829)
Siyuan Hu

Institutions

Zhejiang Chinese Medical University (CN)
Ministry of Education (NZ)
Jinggangshan University (CN)
Ministry of Education (TH)
Buchang Pharma (China) (CN)

Publication Details

Journal: Endocrine Metabolic & Immune Disorders - Drug Targets
Published: 2025-09-25
DOI: https://doi.org/10.2174/0118715303398054250823130459
Primary Topic: Pharmacological Effects of Natural Compounds
Type: article
Field-Weighted Citation Impact: 0.00

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article

Unraveling the Immunomodulatory Mechanisms of Quan-du-zhong Capsule in Diabetic Kidney Disease via Integrated Network Pharmacology and Experimental Validation

Bo Xie, Xunli Xiao, Zunyou Wu, Cong Zhou et al.

Sep 25, 2025

Endocrine Metabolic & Immune Disorders - Drug Targets

Pharmacological Effects of Natural Compounds

article

Unraveling the Immunomodulatory Mechanisms of Quan-du-zhong Capsule in Diabetic Kidney Disease via Integrated Network Pharmacology and Experimental Validation

Bo Xie, Xunli Xiao, Zunyou Wu, Cong Zhou, Jun Xiao, Guohua Liu, Siyuan Hu

September 25, 2025article en

Abstract

This study illustrates the mechanism by which QDZ upregulates FOS expression and modulates the MAPK signaling pathway, thereby regulating immune cell function in DKD. These findings provide novel insights to inform future research and development of QDZ-based DKD therapies.

Endocrine Metabolic & Immune Disorders - Drug TargetsVol. 25

Zhejiang Chinese Medical University (CN), Ministry of Education (NZ), Jinggangshan University (CN), Ministry of Education (TH), Buchang Pharma (China) (CN)

Openalex Percentile: Top 65%

Pharmacological Effects of Natural Compounds

DOI Source OpenAlex

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Unraveling the Immunomodulatory Mechanisms of Quan-du-zhong Capsule in Diabetic Kidney Disease via Integrated Network Pharmacology and Experimental Validation — Bo Xie, Xunli Xiao, et al. · Endocrine Metabolic & Immune Disorders - Drug Targets (2025) | TGRS Research Map | TGRS