Isoflurane Promotes Neuroinflammation and Induces Cognitive Impairment Through the miR‐3099‐5p/AQP4 Axis
miR-3099-5p mediates isoflurane-induced neurotoxicity via AQP4 regulation. Its inhibition alleviates cognitive impairment and neuroinflammation, providing a novel therapeutic target for anesthesia-related neural damage and potential neuroprotective drug development.
Authors
- Xiangyu Meng (ORCID: https://orcid.org/0000-0002-6876-0028)
- Huiwen Guan
- Pingxiu Tang (ORCID: https://orcid.org/0009-0001-1789-3269)
- Xiao Zu
- Peng Zhao
- Xufang Sun (ORCID: https://orcid.org/0000-0002-5264-847X)
- Liucai Sui
- Xiao Zhang
- Bing Zhang (ORCID: https://orcid.org/0000-0001-7592-1195)
- Jiahao Zhang (ORCID: https://orcid.org/0000-0003-2097-0840)
- Cheng Sheng-quan
- Junjie Feng (ORCID: https://orcid.org/0009-0001-5861-2742)
Institutions
- Shandong University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shandong Provincial Hospital (CN)
- Second Affiliated Hospital of Jilin University (CN)
- Shuguang Hospital (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Synapse
- Published
- 2025-09-28
- DOI
- https://doi.org/10.1002/syn.70032
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00