Expert consensus on the clinical management of HIV late presentation
Abstract With the advancement of combination antiretroviral therapy (cART), the global number of new human immunodeficiency virus (HIV) infections and HIV-related mortality has significantly declined. However, the high proportion of “late presentation” (defined as presenting to care with a low CD4 cell count or AIDS-defining events) among HIV-infected individuals remains a significant challenge in HIV prevention and treatment. HIV late presentation is associated with increased clinical risk, complex management, and higher risk of transmission, and represents a significant barrier to achieving the “95-95-95” targets and ending the HIV epidemic. Currently, both nationally and internationally, there is a lack of specific clinical guidelines for this population. Therefore, the China Association for Promotion of Health Science and Technology convened experts in the field to discuss the definition, clinical characteristics, risks, and cART of late presenters based on the latest research evidence and clinical practices both domestically and internationally. Specific recommendations were formulated to guide healthcare professionals in their clinical practice.
Authors
- Linghua Li (ORCID: https://orcid.org/0000-0001-5711-8681)
- Ruichao Lu
- Rugang Wang (ORCID: https://orcid.org/0000-0001-7617-9607)
- Taisheng Li (ORCID: https://orcid.org/0000-0002-7050-5675)
- Yaokai Chen (ORCID: https://orcid.org/0000-0002-3229-0108)
- Mengjie Han (ORCID: https://orcid.org/0000-0001-6552-4137)
- Yongtao Sun (ORCID: https://orcid.org/0000-0001-7884-7007)
- Wei Lyu (ORCID: https://orcid.org/0000-0001-7441-9961)
- Tong Zhang (ORCID: https://orcid.org/0000-0003-0179-8555)
- Hui Wang (ORCID: https://orcid.org/0000-0002-9524-8337)
- Yingquan Zhou
- Ping Ma (ORCID: https://orcid.org/0000-0002-0585-7885)
- Lijun Sun (ORCID: https://orcid.org/0000-0002-5954-6679)
- Hongxin Zhao (ORCID: https://orcid.org/0000-0002-7856-2877)
- Huiqin Li (ORCID: https://orcid.org/0000-0002-6319-1196)
- Weiping Cai (ORCID: https://orcid.org/0000-0002-4515-6098)
- Qingxia Zhao
- Hongxia Wei (ORCID: https://orcid.org/0009-0008-2153-9132)
- Yun He (ORCID: https://orcid.org/0000-0003-1145-3833)
- Fujie Zhang (ORCID: https://orcid.org/0000-0003-3898-217X)
- Ning Wang (ORCID: https://orcid.org/0000-0001-6877-9741)
Institutions
- Capital Medical University (CN)
- Chinese Center For Disease Control and Prevention (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Southern University of Science and Technology (CN)
- Tianjin People's Hospital (CN)
- Guangxi Longtan Hospital (CN)
- Beijing YouAn Hospital (CN)
- Pulmonary Hospital of Lanzhou (CN)
- Beijing Ditan Hospital (CN)
- Nanjing Second Hospital (CN)
- The Sixth People's Hospital of Zhengzhou (CN)
- Chongqing Public Health Medical Center (CN)
- Tang Du Hospital (CN)
- Guangzhou Eighth People's Hospital (CN)
- Yunnan Provincial Infectious Disease Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- Seventh People's Hospital of Dalian (CN)
Publication Details
- Journal
- Infectious Diseases & Immunity
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1097/id9.0000000000000182
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00