Comparison of Oral and Intranasal Midazolam Premedication in Children Undergoing Cleft Lip and Palate Surgery: A Randomized Controlled Trial
Midazolam oral administration is associated with enhanced emotional tolerance in pediatric patients undergoing cleft-related surgeries compared with intranasal administration, with similar efficacy and safety profiles. This route may be preferable in younger or anxious children to minimize preoperative stress.
Authors
- Atsushi Abe (ORCID: https://orcid.org/0000-0001-8215-2769)
- Takuro Sanuki (ORCID: https://orcid.org/0000-0002-1347-2627)
- Izumi Kuroda
- Naoko Tachi (ORCID: https://orcid.org/0000-0002-0439-4874)
- Shota Tsukimoto (ORCID: https://orcid.org/0000-0002-3460-3630)
- Aiji Sato (ORCID: https://orcid.org/0000-0003-0182-2543)
- Mayumi Hashimoto
Institutions
- Aichi Gakuin University (JP)
- Nagasaki University Hospital (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- Cureus
- Published
- 2025-09-28
- DOI
- https://doi.org/10.7759/cureus.93437
- Primary Topic
- Cleft Lip and Palate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00